To help sort through and clarify some of the issues around herpes testing, The Helper spoke with a well-known expert on the subject, Rhoda Ashley Morrow, PhD, Professor of Laboratory Medicine at the University of Washington School of Medicine. One is that they infer that a low index value means that infection has occurred recently. For those that have an index value that falls in a low positive range, between 0.9 and about 3.5, repeat or confirmatory testing is a reasonable option. IgM antibodies are produced very soon after an infection. 4) A positive IgG to herpes does not tell you when you acquired the infection, just that at some point you did. Basically, if you test positive for herpes type 1 and negative for 2 that does not mean you don’t have genital herpes. Is there a false positive rate on that test is for a newborn? The presence of IgM herpes simplex virus (HSV) antibodies indicates acute infection with either HSV type 1 or 2. The presence of IgG-class antibodies to either HSV type 1 or 2 does not differentiate between remote infection and acute disease. The predictive value of positive or negative results depends on the prevalence of disease and the pretest likelihood of HSV-1 and HSV-2.
Dr. Harold Fisher/Getty ImagesThe herpes simplex virus can cause oral or genital outbreaks. Does testing positive for herpes mean you will inevitably have outbreaks? These newer tests detect IgG antibodies directed against the cell wall protein specific for HSV-1 or HSV-2. If your value is less than 3.5, ask to be tested again with a different test, preferably with another antibody test called the Western blot. Never had an outbreak, lesion or noticeable symptoms and I know I’ve had it for at least a year and a half now. My doctor said my IgG antibody level indicates I may never have an HSV-2 outbreak. Hi Adrial, I read on medhelp that any score under 3.5 should be either tested again Ina few months or go for WB. Unless the HSV2 value is above something like 3 or 3.5 (I can’t remember exactly), it may be a false positive. Do you agree that a result of 6.5 indicates a recent initial infection?
Serologic assays that utilize herpes simplex virus (HSV) type-specific glycoproteins G-1 (HSV-1) and G-2 (HSV-2) to discriminate between antibodies against HSV-1 and HSV-2 are sensitive and specific. Similarly, the median of mean positive index values for women whose HSV-2 antibody status reverted from positive to negative was lower than that for those women who did not serorevert (1. If the high positive control index value was less than 3.5, the test results were considered invalid and it was necessary to repeat the assay. IgG antibody to HSV detected which may indicate a current or past HSV infection. 10 IV or greater, then HSV 1 gG-Specific IgG and HSV 2 gG-Specific IgG will be added. What does it mean if I was told that my Herpes titer was low and indicates prior infection. Can you have Herpes with no symptoms? 10 are considered positive, however, most people in the know will recommend getting retested if your HSV2 result is below 3.5, especially if you have a preexisting case of HSV1 The problem is everyone wants answers; they wanna know how bad it is, how long they’ve had it, bla bla bla. A 4.6 is a positive value on a HerpeSelect blood test.
Herpes Tests Are Not Always Accurate
It also can’t accurately distinguish herpes simplex virus from other herpes viruses, like chicken pox. If you were positive by IgM and not by IgG, and at least 3-4 months have passed since your test, ask for an IgG test. If it is positive (at greater than 3.5), then you have old infection. Here’s the problem: If you get a pap and the PCR HSV test portion is negative for herpes, does that mean you don’t have herpes? Evaluation of a New Point-of-Care Serologic Assay for Herpes Simplex Virus Type 2 Infection. Increasing the cutoff index value to 3.5 increased the test sensitivity to 100. First, they allow for same-visit diagnosis and immediate counseling and treatment, if indicated. The test requires only 2 steps but does not yet have a Clinical Laboratory Improvement Amendments waiver. When a person is first infected with HSV 1, 74 of them do NOT develop any symptoms. Borderline test result for herpes can either mean 2 things: 1) False positive 2) Early infection You can get yourself re-tested for herpes in about 2-3 months time just to be sure. If your value is less than 3.5, ask to be tested again with a different test, preferably with another antibody test called the Western blot. But probabilistically, you most likely do have HSV-2, so it’s worth thinking about how you move forward from that point. The presence of antibodies for HSV-2, the most common cause of genital herpes, almost always indicates genital herpes infection with the type 2 virus. Varicella zoster infections (chickenpox, herpes zoster) are usually diagnosed clinically, but laboratory diagnosis is recommended when the clinical picture is atypical or complicated. Monitoring of VZV viral load in blood and CSF can be done in complicated cases which fail to respond to treatment. Generally, the VIDAS VZV screen for IgG is not indicated. 3.5.4 Predictive value and Relevant Populations. The accurate herpes blood tests detect IgG antibodies. The challenge here is that the time it takes for IgG antibodies to reach detectable levels can vary from person to person. However, since most cases of genital herpes are caused by HSV-2, a positive result for type-2 antibodies most likely indicates genital herpes. I have symptoms every single day. Feelbroken jason50784 19 April 2015 at 17:49 GMT Jason, came across this again and noticed the low score on the hsv 2 being under 3.5.
Longitudinal Reliability Of Focus Glycoprotein G-based Type-specific Enzyme Immunoassays For Detection Of Herpes Simplex Virus Types 1 And 2 In Women
Levels of IgG rise during the active infection, then stabilize as the parvovirus B19 infection resolves. In general, most people who have or have had parvovirus B19 do not require laboratory testing because illness does not typically last more than 5-7 days and symptoms are usually mild. In contrast, testing for herpes simplex virus type 2 (HSV-2) infection is not only not recommended but actively discouraged.