Human herpesvirus-8 (HHV-8) seroprevalence among the general population in the United States is 1 to 5. The herpes family of viruses includes 8 different viruses that affect human beings. HHV1 can also lead to infection in the genital area causing genital herpes usually through oral-genital contact, such as during oral sex. HHV-8 Information on Human herpesvirus 8 (Kaposi’s sarcoma-associate herpes virus) incliuding symptoms, diagnosis, transmission, and treatment.
Although human herpesvirus 8 (HHV-8) is the etiologic agent of Kaposi sarcoma (KS), there are no formal guidelines for the clinical management of HHV-8 infection. Our intent in the present review is to provide a brief background on the biological characteristics of HHV-8 and to outline the research gaps that must be bridged so that the diagnosis, monitoring, and treatment of HHV-8 infection can play a role in the prevention and clinical management of KS. There are eight currently identified members of the human herpes virus family. Reactivation of latent virus leads to recurrent disease – virus travels back down sensory nerves to surface of body and replicates, causing tissue damage:. The symptoms and signs of primary infection with subsequent HHV-8 seroconversion have been described in children, men who have sex with men (MSM), and immunocompromised hosts.
Human herpesvirus 8 (HHV-8, Kaposi’s sarcoma-associated herpesvirus, KSHV) was identified from acquired immunodeficiency syndrome (AIDS)-associated Kaposi’s sarcoma in 1994 (8). BCBL-1, an HHV-8-infected cell line derived from a primary effusion lymphoma, produces HHV-8 particles in the culture supernatant after stimulation by phorbor-ester acetate (32) and up to 20 of primary effusion lymphoma cells were induced to lytic infection. Kaposi sarcoma (KS) is caused by infection with a virus called the Kaposi sarcoma associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8). Description of the cancers associated with the human herpesvirus type 8 (HHV8). Associated Cancer: HHV8 primarily causes Kaposi’s Sarcoma (KS), a type of cancer that affects the skin and soft organs.
Human Herpesvirus 8: Current Issues
But kissing between men may be what spreads human herpes virus 8 (HHV-8), the cause of Kaposi’s sarcoma, according to researchers at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle. Human herpesvirus-8 (HHV-8) is associated with some human diseases including Kaposi s sarcoma and also some B-cell lymphoproliferative disorders. Multiple myeloma or plasma cell myeloma is a hematologic malignancy caused by neoplastic plasma cells which synthesize abnormal amounts of monoclonal immunoglobulins or immunoglobulin fragments 11. Human herpesvirus 8 (HHV-8): A herpesvirus that contributes to the development of Kaposi sarcoma, an otherwise rare form of cancer sometimes seen in AIDS patients, and to some B-cell lymphomas. Treatment is experimental at this time, but anti-viral drugs or beta interferon may be tried. Human herpes virus 8 (HHV8 or it can be called KSHV see below). Human herpesvirus 8 (HHV-8), also known as Kaposi’s sarcoma-associated herpesvirus (KSHV), discovered in 1994, is a human rhadinovirus (gamma-2 herpesvirus). Cultures of primary human monocytes-macrophages from patients with AIDS-associated KS can be infected with HHV-8, and treatment with cytokines seems to enhance viral production and allow the cells to maintain the virus for a longer period (21). A type of virus that causes Kaposi sarcoma (a rare cancer in which lesions grow in the skin, lymph nodes, lining of the mouth, nose, and throat, and other tissues of the body).
Human Herpesvirus 8 (HHV-8)
Primary human herpesvirus 8 infection generates a broadly specific CD8+ T-cell response to viral lytic cycle proteins. Incidence and clinical signs and symptoms of primary HHV-8 infection. With the exception of HHV-8, which causes Kaposi’s sarcoma in patients with AIDS, reactivation of HHVs can produce one or more of the following complications: meningitis, encephalitis, myelitis, vasculopathy, ganglioneuritis, retinal necrosis and optic neuritis. The tumor is caused by the human herpesvirus 8, an infection more likely to occur in people with compromised immunity, such as people with HIV or taking immunosuppressant drugs for an organ transplant. There are eight known herpes viruses that infect humans: herpes simplex virus (HSV)(types 1 and 2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), and the recently described human herpes virus 6, human herpes virus 7, and human herpes virus 8. There are eight known herpes viruses that infect humans: herpes simplex virus (HSV)(types 1 and 2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), and the recently described human herpes virus 6, human herpes virus 7, and human herpes virus 8.