First-episode infections are more extensive: primary lesions last two to six weeks versus approximately one week for lesions in recurrent disease. Recurrent HSV outbreaks usually are milder than the initial episode: there typically are fewer grouped lesions (Figures 2 and 3), and viral shedding occurs at a lower concentration and for a shorter duration (i. These drugs can be used for episodic treatment or long-term suppressive therapy. Reviews and ratings for acyclovir when used in the treatment of herpes simplex. I had a small outbreak last year but through it was from my new soap and another out break this year. The pills don’t cure the outbreaks but they do make them bare able and waaaaaaay less annoying. Went out, got Acyclovir and again, within 24hours what was bound to be a huge long drawn out cold sore had stopped, shrunk and began healing.