Acyclovir Injection is a formulation for intravenous administration. Each 20 mL vial contains 500 mg of acyclovir and 49 mg of sodium, and each 40 mL vial contains 1000 mg acyclovir and 98 mg of sodium. Each vial contains 250mg of aciclovir as the sodium salt For a full list of excipients, see section 6. Route of administration: Slow intravenous infusion over one hour. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2-8 C, unless reconstitution has taken place in controlled and validated aseptic conditions. Each vial of 10 ml of solution contains 250 mg aciclovir (sodium salt formed in situ)Each vial of 20 ml of solution contains 500 mg aciclovir (sodium salt formed in situ)Each vial of 40 ml of solution contains 1 g aciclovir (sodium salt formed in situ) Excipients: 1 ml of solution contains 2. In obese patients dosed with intravenous aciclovir based on their actual body weight, higher plasma concentrations may be obtained (see 5.
At 25 deg C, there was no loss in potency after 30 days of storage, and at 5 deg C, the drug had begun to precipitate within 5 days. The drug appears to be very stable in both admixtures. There was no decomposition after 37 days of storage at 25 degrees C or 5 degrees C. The manufacturer-recommended expiry date of 24 h at 25 degrees C is too conservative. ZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analog active against herpesviruses. Acyclovir sodium for injection is a sterile lyophilized powder for intravenous administration only.
Acyclovir (acyclovir sodium) – Drug Summary. Fresenius Kabi USA, LLC. BRAND NAMES. Zovirax Injection (Discontinued), Acyclovir Injection. Medscape – Herpes simplex, zoster-specific dosing for Zovirax (acyclovir), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. 10-15 mg/kg IV q8hr for 10 days; up to 14-21 days reported. Storage. Consult the product instructions and your pharmacist for storage details. Keep all medicines away from children and pets.
Stability Of Acyclovir Sodium After Reconstitution In Sodium Chloride Inection And Storage In Polypropylene Syringes For Pediatric Use